The product should be administered orally, once daily. To facilitate administration, the required daily dose should be placed in a small amount of water and/or mixed with molasses or other sweetener and agitated until dissolved.
How long does it take for Prascend to work?
Clinical improvement is usually expected within 6-12 weeks of starting Prascend treatment, however the length of time between initiation of treatment to being able to see a response can vary from one horse or pony to another.
What is the best feed for a horse with Cushings?
Horses and ponies diagnosed with PPID/Cushing’s Disease should be fed a low sugar and starch diet. As alfalfa is naturally low in both sugar and starch, there are a number of feeds in our range that are suitable.
What happens if Cushing’s is left untreated in horses?
If a horse has untreated Cushing’s Disease, it is more likely to develop laminitis and the laminitis will be more difficult to control. If an equine has any of the clinical signs suggestive of Cushing’s, a blood sample can be taken to check ACTH levels in the blood.
How do you give a horse pergolide?
“The recommended dose for horses starts at 0.001 mg/kg/day orally, which equates to about 0.5 mg for an average horse. Some ponies have success on 0.25 mg/day,” said Laura Petroski, a veterinarian for Kentucky Equine Research. “Clinical improvement should be noted within a few weeks.
Can you crush pergolide?
Do not ingest the product. PRASCEND tablets should not be crushed due to the potential for increased human exposure. Pergolide, like other ergot derivatives, may cause emesis, dizziness, lethargy or low blood pressure. Pregnant or lactating women should wear gloves when administering this product.
What are the side effects of Prascend in horses?
Treatment with PRASCEND has been observed to cause inappetence, with most cases being transient. Weight loss, lethargy and behavioral changes may be observed in some horses. If severe, a temporary reduction of dose may be necessary. PRASCEND has not been evaluated in breeding, pregnant or lactating horses.
How long does it take for pergolide to work on a horse?
Pergolide does not accumulate in the horse’s body, and steady levels of pergolide are realized within three days of starting treatment; Pergolide is cleared from the system quickly, with a half-life less than 12 hours; and.
Can Prascend be given every other day?
Giving 0.5 mg every other day – the datasheet states that Prascend should be given once daily. As the average half life of pergolide has been found to be around 6 hours in horses (Abra Wright Pharmacokinetics of pergolide in normal mares, MSc thesis 2009), extending the time between doses seems counter-intuitive.
What is the half life of PRASCEND?
It has been demonstrated that Pergolide is rapidly absorbed with a short time to peak concentration. Peak concentrations (Cmax) following the dose of 10 µg/kg were low and variable with a mean of ~ 4 ng/mL and a mean terminal half life (T1/2) of ~ 6 hours.
How Zip’s Signs of Cushing’s Disease Were Quickly Noticed
Prascend® (pergolide tablets) Horse Owner Stories – YouTube
How to Give a Horse Oral Medications – YouTube